肥胖和相关代谢疾病的发病机制及防治。

2021.7- 太阳成集团tyc234cc创新港转化医学研究院 分子转化医学研究所 炎症生物学团队 Co-PI 2017.7- 太阳成集团tyc234cc医学部基础医学院人体解剖与组织胚胎系 副教授 2017.1-2017.6 太阳成集团tyc234cc生命科学与技术学院 副教授 2014.10-2016.10 太阳成集团tyc234cc前沿科学技术研究院线粒体生物医学中心 PI 小组主任 3 类 2012.7–2014.9 美国加州 City of Hope Beckman 研究所糖尿病与代谢疾病系 博士后 2009.4–2012.4 英国利物浦大学医学院肥胖与内分泌系 博士后

1. 陕西省自然科学基金一般项目（面上）2024.1-2025.12 主持

2. 国家自然基金面上项目，2019.01-2022.12，主持，已结题

3．国家自然科学青年项目，2017.01-2019.12，主持，已结题

4．第 11 批中国博士后基金特别资助, 2018.1-2019.12, 主持，已结题

5．第 61 批中国博士后科学基金二等资助, 2017.1-2019.12, 主持，已结题

6．陕西省博士后基金（一等资助），2018.01-2019.12, 主持， 已结题

7．陕西省自然科学青年基金，2016.01-2017.12，主持，已结题

8. 太阳成集团tyc234cc基本科研业务费（国际前沿与自由创新类项目） (xjj2015049) 2015.1-2017.12 主持，已结题

代表性论文 （第一作者或通讯作者文章）

1. Chang K, Lin L, Cui T, Zhao H, Li J, Liu C, Gao D*, Lu S*.Zinc-a2-Glycoprotein Acts as a Component of PNN to Protect Hippocampal Neurons from Apoptosis. Mol Neurobiol. 2023 Nov 25. doi: 10.1007/s12035-023-03771-4.(* co-corresponding author) (5- year：5.1)

 2. Li X, Ren Y, Chang K, Wu W, Griffiths HR, Lu S, Gao D. Adipose tissue macrophages as potential targets for obesity and metabolic diseases. Front Immunol. 2023 Apr 19;14:1153915. doi: 10.3389/fimmu.2023.1153915. eCollection 2023. (5-year：8.0)

3. Ren Y, Zhao H, Yin C, Lan X, Wu L, Du X, Griffiths HR, Gao D*. Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation. Front Endocrinol (Lausanne). 2022 Jul 14;13:873699. doi: 10.3389/fendo.2022.873699. eCollection 2022. (5-year：5.9)

4. Gao D, Hu S, Zheng X, Lin W, Gao J, Chang K, Zhao D, Wang X, Zhou J, Lu S, Griffiths HR, Liu J. SOD3 is secreted by adipocytes and mitigates high-fat diet-induced obesity, inflammation, and insulin resistance. Antioxid Redox Signal. 2020 Jan 20;32(3):193-212. (5-year: 8.2)

 5. Wang X#, Zhao D#, Cui Y, Lu S, Gao D*, Liu J*. Pro-inflammatory macrophages impair skeletal muscle differentiation in obesity through secretion of TNFα via sustained activation of p38 MAPK. J Cell Physiol. 2019 Mar;234(3):2566-2580. (*co-corresponding author) (5-year：5.9)

6. Lin W, Liu Z; Zheng X, Gao D*, Tian Z* High-salt diet affects amino acid metabolism in plasma and muscle of Dahl salt-sensitive rats. Amino acids. 2018 Oct;50(10):1407-1414.(* co-corresponding author) (5-year IF：3.5)

7. Jin L*, Gao D*, Feng T, Tremblay JR, Ghazalli N, Luo A, Rawson J, Quijano JC, Chai J, Wedeken L, Hsu J, LeBon J, Walker S, Shih HP, Mahdavi A, Tirrell DA, Riggs AD, Ku HT Cells with surface expression of CD133highCD71low are enriched for tripotent colony-forming progenitor cells in the adult murine pancreas.Stem Cell Res. 2016 Jan;16(1):40-53. (* co-first author) (IF： 3.929)

8. Gao D, Madi M, Ding C, Fok M, Steele T, Ford C, Hunter L, Bing C. Interleukin1 β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes. Am J Physiol Endocrinol Metab. 2014 Aug ;307(3):E289-304 (IF：3.825， 5-year IF：4.66)

9. Gao D, Trayhurn P, Bing C. 1,25-Dihydroxyvitamin D3 inhibits the cytokineinduced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes. Int J Obes (Lond). 2013 Mar;37(3):357-65. (IF：5.337)

10. Gao D, Pararasa C, Dunston CR, Bailey CJ, Griffiths HR. Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis. Free Radic Biol Med. 2012 Aug 15;53(4):796-806 (IF：5.784，5-year IF： 5.982)

11. Gao D, Bing C. Macrophage-induced expression and release of matrix metalloproteinase 1 and 3 by human preadipocytes is mediated by IL-1β via activation of MAPK signaling. J Cell Physiol. 2011 Nov;226(11):2869-80. (IF: 4.155)

12. Gao D, Trayhurn P, Bing C. Macrophage-secreted factors inhibit ZAG expression and secretion by human adipocytes. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):135-42. (IF：3.859, 5-year IF: 3.974)

13. Mracek T*, Gao D*, Tzanavari T, Bao Y, Xiao X, Stocker C, Trayhurn P, Bing C. Downregulation of zinc-{alpha}2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-alpha in adipocytes. J Endocrinol. 2010 Feb;204(2):165-72. (*co-first author) (IF：4.498)

14. Gao D, Griffiths HR, Bailey CJ. Oleate protects against palmitate-induced insulin resistance in L6 myotubes. Br J Nutr. 2009 Dec;102(11):1557-63. (IF: 3.311)

15. Gao D, Bailey CJ, Griffiths HR. Metabolic memory effect of the saturated fatty acid, palmitate, in monocytes. Biochem Biophys Res Commun. 2009 Oct 16;388(2):278-82 (IF: 2.371)