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景王慧 |
教育经历：
(1) 2010-09至2014-10, 澳门大学, 生物医药学, 博士, 导师: 王一涛教授
(2) 2008-09至2010-7, 澳门大学, 中药学, 硕士, 导师: 王一涛教授
(3) 2004-09至2008-7, 山西医科大学, 药学, 学士
工作经历：
(1) 2018-11至现在, 太阳成集团tyc234cc, 医学部药学院, 副教授
(2) 2015-3至2018-11, 太阳成集团tyc234cc, 医学部药学院, 讲师
(3) 2016-1至2017-12, 美国加州大学欧文分校，医学院, 博士后, 导师: Nosratola D. Vaziri
（1）国家自然科学基金委员会，面上项目，82174059，基于“肠道菌-Trp-AhR”轴解析戊己丸修复UC肠粘膜屏障的作用机制，2022.01-2025.12，在研，主持。
（2）国家科技部，高端外国专家引进项目，G2021170018L，国际中药质量标准，2021.01-2022.12，在研，主持。
（3）陕西省科技厅，一般项目-社会发展领域，2022SF-123，脾胃中药治疗炎症性肠病的作用机制及开发，2022.01-2023.12，在研，主持。
（4）企业，横向课题，金胆粉抗溃疡性结肠炎作用初步研究，2022.01-2022.12，在研，主持。
（5）上海交通大学系统生物医学教育部重点实验室，开放课题，KLSB2019KF-01，基于胆汁酸代谢调节探讨白术-白芍对UC的作用机制，2020.01-2021.12，已结题，主持。
（6）中国博士后科学基金会，面上项目，2019M653671，基于肠道菌群紊乱对肠屏障的影响探讨黄连抗UC的作用机制，2019.06-2021.12，已结题，主持。
（7）陕西省中医药管理局项目，基于胆汁酸代谢与肠屏障功能探讨白术-白芍对UC的作用与机制（2019-ZZ-ZY007）3万元，2019.09-2020.12，已结题，主持。
（8）国家自然科学基金委员会，青年科学基金项目，81603370，黄连通过肠道菌调节肠外排蛋白P-gp修复UC肠屏障损伤的作用机制研究，2017.01-2019.12，已结题，主持。
（9）陕西省科技厅，青年科学基金项目，2017JQ8006，小檗碱通过肠道菌调节肠P-糖蛋白修复UC肠屏障损伤的作用机制，2017.01-2018.12，已结题，主持。
（10）太阳成集团tyc234cc，中央高校基本科研业务经费学科交叉项目，肠道菌群对溃疡性结肠炎P-糖蛋白调节机制研究，2015085，2015.01-2016.12，已结题，主持。
（一）科研奖励：
中国中西医结合学会科学技术奖一等奖，基于肺肠疾病关联与药物归经的“肺与大肠相表里”理论实证研究，高思华; 崔乃强; 王一涛; 傅强; 林燕; 燕如; 王键; 王平; 张淑坤; 倪金霞; 毕惠嫦; 莫芳芳; 景王慧; 张德政; 纪立金。
（二）代表性论文
(1)Wanghui Jing, Min Zhu, Fushuo Wang, Xinxin Zhao, Sijing Dong, Yinyue Xu, Sicen Wang, Jianhai Yang*, Ke Wang*, and Wenguang Liu, Hyaluronic Acid-Melatonin Nanoparticles Improve the Dysregulated Intestinal Barrier, Microbiome and Immune Response in Mice with Dextran Sodium Sulfate-Induced Colitis. Journal of Biomedical Nanotechnology, 2022, 18:175-184
(2)Hua Luo, Guiqing Cao, Chun Luo, Dechao Tan, Chi Teng Vong, Yinyue Xu, Sicen Wang, Haitao Lu*, Yitao Wang*, Wanghui Jing*, Emerging pharmacotherapy for inflammatory bowel diseases, Pharmacol Res, 2022, 178:106146.
(3)Sijing Dong; Min Zhu; Ke Wang; Xiaoye Zhao; Longlong Hu; Wanghui Jing*; Haitao Lu*; Sicen Wang; Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism. Pharmacol Res, 2021, 171:105767.
(4)Wanghui Jing#; Sijing Dong#; Xialin Luo#; Jingjing Liu; Bin Wei; Wei Du; Lin Yang; Hua Luo; Yitao Wang; Sicen Wang*; Haitao Lu*; Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites. Pharmacol Res, 2021, 164:105358.
(5)Wanghui Jing*; Yasaman Safarpour; Ting Zhang; Pengqi Guo; Guoning Chen; Xiaoming Wu; Qiang Fu*; Yitao Wang; Berberine Upregulates P-Glycoprotein in Human Caco-2 Cells and in an Experimental Model of Colitis in the Rat via Activation of Nrf2-Dependent Mechanisms, J Pharmacol Exp Ther, 2018, 366: 332-340.
(6)Wanghui Jing*; Ane C. F. Nunes; Ted Farzaneh; Mahyar Khazaeli; Wei Ling Lau; Nosratola D. Vaziri*; Phosphate Binder, Ferric Citrate, Attenuates Anemia, Renal Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in 5/6 Nephrectomized CKD Rats, J Pharmacol Exp Ther, 2018, 367:129-137.
(7)Wanghui Jing*, Bahman Jabbari, Nosratola D Vaziri*. Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier. Am J Transl Res. 2018, 10(7):2137-2147.
(8)Wanghui Jing, Nosratola D Vaziri*, Ane Nunes1, Yasunori Suematsu1, Seyed Farzaneh, Mahyar Khazaeli1, Hamid Moradi*, LCZ696 (Sacubitril/valsartan) ameliorates oxidative stress, inflammation, fibrosis and improves renal function beyond angiotensin receptor blockade in CKD. Am J Transl Res. 2017, 9 (12): 5473-5484.
(9)Wanghui Jing, Xuejiao Gao, Beilei Hana, Bin Weia, Nan Hua, Sai Lia, Ru Yan* and Yitao Wang, Mori Cortex regulates P-glycoprotein in Caco-2 cells and colons from colitic rats via gut bacteria dependent/independent mechanisms. RSC Adv., 2017, 7, 2594-2605.
(10)Wanghui Jing*, Ruilin Liu, Wei Du, Zhimin Luo, Pengqi Guo, Ting Zhang, Aiguo Zeng, C Chang, Qiang Fu*, Pharmacokinetic and Metabolic Characteristics of Herb-derived Khellactone Derivatives, A class of Anti-HIV and Anti-hypertensive Drug Candidates: A Review, Molecules, 2016, 21 (3): 314-318.
(11)Wanghui Jing, Ru Yan*, Yitao Wang, A practical strategy for chemical profiling of medicinal herbs using ultra-high performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry: a case study of Mori Cortex. Analytical Method. 2014, DOI: 10.1039/c4ay02196g.
(12)Wanghui Jing, Yuelin Song, Ru Yan*, Yitao Wang, Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. J Pharm Biomed Anal. 2013, 77: 175-188.
(13)Wanghui Jing, Yueling Song, Ru Yan, Huichang Bi, Pengtao Li, Yitao Wang. Transport and metabolism of (±)-praeruptorin A in Caco-2 cell monolayers. Xenobiotica. 2011, 41(1): 71-81.
